Hydration vs. skin permeability to nicotinates in man

摘要: Background/aims: Prolonged skin occlusion increases stratum corneum water content and often permeability irritant dermatitis. As wetness from wearing diapers is considered an important factor favouring the onset of diaper dermatitis, optimal diapering might decrease hyperhydration Our aim to define quantitative relationship between nicotinate ester (a model penetrant) hydration, as measured by evaporation rate (WER), decay curves (at individual time points) WER-area under curve (WER-AUC); also determine level hydration nicotinates following a simulation. Methods/results: Nine healthy Caucasian adult women were enrolled after prescreening procedure (time peak redness response nicotinate); each received three wet occlusive patches for different exposure times (10 min, 30 min, 3 h) two (3 8 h). Prior patching or forearms, basal values WER, blood flow volume (BFV), capacitance (Cap) (a*) on premarked sites (a, b, c d). Immediately, patch removal, 20 µL (methyl hexyl nicotinate) was applied its respective site b). The WER Cap readings recorded at designated (c d) with intervals applications: 0, 5, 10, 15 20 min. a* BFV measurements made challenged b) 15, 20, 30, 40, 60 min. Results: WER-AUC thus, hyperhydration, increased time, but there no statistical difference 3 8 h sites. All patched had significantly (P < 0.05) in comparison control (undiapered unpatched skin). patches, not diapers. degree time-course did vary extent compared non-hydrated skin. BFV-AUC show significant increase sites; varied sites, some higher than site. Conclusion: Wet proportional time. Permeation hydrated vs. control, even only 10 min exposure. For these permeants, we found evidence permeation rates once relatively low threshold achieved (e.g. that reached patch). data showed meaningful differences either simulation suggested method superior measuring absolute hyperhydration. We believe this suitable evaluating quality product performance, well pharmacologic assays therapy.