Microvascular tissue as a platform technology to modify the local microenvironment and influence the healing cascade.

摘要: Aims: Profiling of microvascular tissue allows identification components that stimulate wound healing. Here we study those elements for biological effect and establish clinical proof-of-concept using a graft (mVASC®) in chronic refractory wounds. Methods: mVASC was characterized fragments protein composition, evaluated angiogenic potential preclinical models, applied clinically to series nonhealing wounds with compromised vascularity different etiologies. Results: increased endothelial cell migration vitro angiogenesis mouse ingrowth hindlimb ischemia models. Clinically, stimulated neovascularization, granulation epithelialization, complete durable Conclusion: Microvascular contains relevant repair can be enable or accelerate the closure challenging