Vascular wall extracellular matrix proteins and vascular diseases

摘要: Extracellular matrix proteins form the basic structure of blood vessels. Along with providing structural support to vessels, interact different sets vascular cells via cell surface integrin or non-integrin receptors. Such interactions induce de novo synthesis new during vessel development remodeling. Under pathological conditions, undergo proteolytic processing, yielding bioactive fragments influence wall Vascular also produce alternatively spliced variants that production interrupt homeostasis, leading increased stiffness; migration, proliferation, death; leakage and rupture. Destruction leads blood-borne leukocyte accumulation, neointima formation within wall; vessels prone uncontrolled enlargement flow diastole; tortuous vein development; neovascularization from existing tissue microvessels. Here we summarize discoveries related past decade clinical studies in humans animals — expression cross-linking, assembly, degradation under physiological including atherosclerosis, aortic aneurysms, varicose veins, hypertension.