Serum Mimecan Is Associated With Arterial Stiffness in Hypertensive Patients

摘要: Background Mimecan plays an important role in endothelial and vascular smooth muscle cell integrity may be involved the pathology of arterial stiffness. However, mimecan stiffness patients with hypertension is not well defined. Methods Results A total 116 54 healthy controls were enrolled investigation. Hypertensive divided into 2 groups: group (brachial‐ankle pulse wave velocity [baPWV] ≥1400 cm/s; n=83) without (baPWV <1400 n=33). noninvasive measure was performed using (PWV) measurement baPWV. had higher baPWV, mimecan, endothelin 1 (ET‐1) than controls. The lower ankle‐brachial pressure index (ABI) those In hypertensive patients, inversely correlated ABI ( P <0.05) positively ET‐1, cholesterol. On multivariable logistic regression analysis, diastolic blood pressure, creatinine independent predictors <0.05). Conclusions levels are Increased plasma independently associated increased as assessed by