Monthly intra-individual variation in lipids over a 1-year period in 22 normal subjects

摘要: Abstract Objectives: Previous reports on biological variation in lipids differ widely the time interval between sampling, number of samples analyzed per patient and total study period. The present investigation was carried out to determine monthly intra-individual over 1 year establish whether there a consistent change lipid values summer months. importance taking this into consideration during assessment risk coronary heart disease (CHD) also examined. Design methods: Cholesterol, triglycerides, HDL, apo A1, B were measured at intervals for 12 months 22 healthy, free-living volunteers (11 females, 11 males) by standardized methods. Results: When compared analytical variation, dominant component changes observed 1-year As expected, triglycerides showed greatest variation; ratio biological/analytical 33.1. Much smaller ratios other with ranging from 4.2 6.8. Different subjects attained their maximum minimum virtually every month year. There significant reductions cholesterol, LDL, A1 while non-significant increase decrease Conclusions: All analytes considerable variation. It is, therefore, important measure sequentially several weeks arrive an average value stratification CHD.