Cross-link immunoprecipitation data to detect polymorphisms lying in splicing regulatory motifs: a method to refine single nucleotide polymorphism selection in association studies.

摘要: In a previous study we showed that prediction tools are useful to select single-nucleotide polymorphisms (SNPs) which potentially affect phenotype and therefore guide genotyping in association studies, thus saving time money. Here use the recently available RNA cross-link immunoprecipitation data analyze several genes involved psychiatric disorders show disease-associated SNPs can splicing process by altering factor binding sites. We point out importance of using psychiatry refine SNP selection methods, explain found plan molecular investigations.