Neuropeptide and kinin antagonists.

摘要: Neuropeptides and kinins are important messengers in the nervous system and--on basis of their anatomical localisation effects produced when substances themselves administered, to animals or human subjects-a significant number them have been suggested a role pain inflammation. Experiments gene deletion (knock-out null mutant) mice parallel experiments with pharmacological receptor antagonists variety species strengthened evidence that peptides, notably substance P calcitonin gene-related peptide (CGRP), pathophysiological nociception. Clinical studies non-peptide now progress determine if blocking action these peptides might utility treatment pain.