The Histochemistry of Tachykinin Systems in the Brain

摘要: After more than 70 years of research it seems an appropriate moment to summarize the progress in substance P (SP)/tachykinin field, not at least because recent FDA approval SP (NK1) antagonist for treatment chemotherapy-induced emesis/nausea. In present review a wide range histochemical studies based especially on immunohistochemistry and situ hybridization, but also ligand binding autoradiography have been compiled give overview distribution three cloned tachykinins, SP, neurokinin A (NKA) B (NKB), as well their receptors (as so far known), NK1, NK2 NK3. The main focus is rat brain, lesser extent human several other species are briefly mentioned. All tachykinins widely distributed often with strong similarity between species. SP/NKA NKB systems complementary, example strongly expressed cortical areas, where NKA comparatively less abundant. addition show complementary patterns, there overlap ligands receptors. However, cases apparent mismatch can be found. suggests that tachykinin involved large number brain functions. It will important task further correlate such functions particular regard possible involvements disease. Here detailed analyses provide information better understand processes.