Gene by Environment Interactions: Impact on Women’s Health

摘要: There is growing appreciation that a particular gene variant can have quite different effects on the expression of phenotype in persons exposed to varying levels environmental stress. It has been reported, for example, among large number stressful life events those carrying short (S) allele serotonin transporter promoter polymorphism (5HTTLPR) will higher depressive symptoms than homozygous long (L) allele, while not so do vary as function genotype. In this chapter I review extensive evidence from research my laboratory shows it important, at least some variants, consider sex/gender another factor addition factors moderate impact given phenotypes influence development and course major diseases. We shown, two independent samples that, men chronic stress present day or childhood, with 5HTTLPR LL genotype increased symptom levels; contrast, women same stressors, SS who levels. aiming identify genetic variants be used high risk developing disease therefore, evaluate only exposures but also moderators expression.