作者: Robert Tam , Pragnesh Joshi , Igor E. Konstantinov
DOI: 10.1016/J.JTCVS.2006.07.029
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摘要: nant or recessive inheritance with variable and incomplete penetrance. Inheritance of DSS in dogs suggests either polygenic autosomal dominant modifiers. Follow-up siblings offspring patients large pedigrees might help revealing the underlying pattern. We used LVOT peak pressure gradient as a surrogate marker for degree subaortic stenosis. Age, independent sex, was found to be significant predictor pressure. This is first time that any such relationship being reported. emphasizes fact screening cardiac murmurs their timely echocardiographic evaluation can lead early diagnosis majority cases DSS. Although exact mode membranous stenosis not clear yet, documented familial clustering implies at least first-degree relatives every patient those systolic should evaluated subclinical disease.