Expression of the chick Sizzled gene in progenitors of the cardiac outflow tract

摘要: Abstract The secreted Frizzled receptor related proteins (Sfrp’s) belong to a protein family that comprises antagonists and modifiers of Wnt BMP signalling. Here we report the isolation expression pattern Sfrp gene “Sizzled” in chick. Sizzled genes, as well closely crescent exist genomes fishes, frogs chicks, but not mammals. chicken (Szl) is initially expressed anterior endoderm gastrulating early head fold embryos. An additional, separate domain develops at posterior end embryo from process stage onwards. Szl transcripts are then detected precardial mesodermal cells, transiently transcribed straight heart tube, later prominently splanchnic mesoderm surrounding arterial pole developing heart, field. These cells subsequently recruited form cardiac outflow tract. cSzl downregulated when septation tract by neural crest derived begins.