Basic fibroblast growth factor infused at different times during bone graft incorporation. Titanium chamber study in rats.
作者： Jian Sheng Wang , Per Aspenberg
DOI: 10.3109/17453679608994678
关键词:
摘要: We investigated the effect of applying basic fibroblast growth factor (bFGF) to a bone graft during different stages incorporation in an infusion chamber model. Bone chambers were implanted bilaterally into rat tibiae. Both connected osmotic minipump. Ingrowing could enter cylindrical interior only at one end. The distance which ingrowing had reached was then measured on histological slides. Specimens also analyzed by 99mTc-MDP scintimetry. buffer 2 weeks from implantation no effects tissue ingrowth or quality. bFGF infused dose either 1.2 12 ng/day. 6 after implantation. higher more marked and used for studying application times.The maximum stimulation as postimplantation found first pos...
sci-hub.se 参考文章(30)
CRAIG A. DIONNE, MICHAEL JAYE, JOSEPH SCHLESSINGER, Mitogenic Effects of Fibroblast Growth Factors in Cultured Fibroblastsa Annals of the New York Academy of Sciences. ,vol. 638, pp. 161- 166 ,(1991) , 10.1111/J.1749-6632.1991.TB49026.X
M.M. Hurley, C. Abreu, G. Gronowicz, H. Kawaguchi, J. Lorenzo, Expression and regulation of basic fibroblast growth factor mRNA levels in mouse osteoblastic MC3T3-E1 cells. Journal of Biological Chemistry. ,vol. 269, pp. 9392- 9396 ,(1994) , 10.1016/S0021-9258(17)37121-1
Per Aspenberg, Karl-Göran Thorngren, L. Stefan Lohmander, Dose-dependent stimulation of bone induction by basic fibroblast growth factor in rats. Acta Orthopaedica Scandinavica. ,vol. 62, pp. 481- 484 ,(1991) , 10.3109/17453679108996650
Martin J Cohn, Juan Carlos Izpisúa-Belmonte, Helen Abud, John K Heath, Cheryll Tickle, Fibroblast growth factors induce additional limb development from the flank of chick embryos Cell. ,vol. 80, pp. 739- 746 ,(1995) , 10.1016/0092-8674(95)90352-6
P. Aspenberg, T. Albrektsson, L.S. Lohmander, K.G. Thorngren, Drug test chamber: a titanium implant for administration of biochemical agents to a standardized bone callus in situ Journal of Biomedical Engineering. ,vol. 10, pp. 70- 73 ,(1988) , 10.1016/0141-5425(88)90029-5
Sevgi B. Rodan, Gregg Wesolowski, Kenneth A. Thomas, Kyonggeun Yoon, Gideon A. Rodan, Effects of Acidic and Basic Fibroblast Growth Factors on Osteoblastic Cells Connective Tissue Research. ,vol. 20, pp. 283- 288 ,(1989) , 10.3109/03008208909023898
Jian-Sheng Wang, Per Aspenberg, Basic fibroblast growth factor enhances bone-graft incorporation: Dose and time dependence in rats Journal of Orthopaedic Research. ,vol. 14, pp. 316- 323 ,(1996) , 10.1002/JOR.1100140222
D. Gospodarowicz, G. Neufeld, L. Schweigerer, Fibroblast growth factor: structural and biological properties. Journal of Cellular Physiology. ,vol. 133, pp. 15- 26 ,(1987) , 10.1002/JCP.1041330405
RUTH K. GLOBUS, JEAN PLOUET, DENIS GOSPODAROWICZ, Cultured bovine bone cells synthesize basic fibroblast growth factor and store it in their extracellular matrix. Endocrinology. ,vol. 124, pp. 1539- 1547 ,(1989) , 10.1210/ENDO-124-3-1539
E. A. Wang, V. Rosen, J. S. D'Alessandro, M. Bauduy, P. Cordes, T. Harada, D. I. Israel, R. M. Hewick, K. M. Kerns, P. LaPan, Recombinant human bone morphogenetic protein induces bone formation. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 2220- 2224 ,(1990) , 10.1073/PNAS.87.6.2220