Biodegradable micro-osmotic pump for long-term and controlled release of basic fibroblast growth factor.
作者： WonHyoung Ryu , Zhinong Huang , Fritz B. Prinz , Stuart B. Goodman , Rainer Fasching
DOI: 10.1016/J.JCONREL.2007.08.024
关键词:
摘要: Microelectromechanical system (MEMS) technology not only provides the possibility of integration multiple functions but also enables more precise control dosing therapeutic agents when window is very limited. Local delivery basic fibroblast growth factor (bFGF) over a specific dose and time course critical for mesenchymal tissue regeneration. However, bFGF degraded quickly in vivo difficulty controlling level impedes its effective use angiogenesis We constructed biodegradable micro-osmotic pumps based on MEMS long-term controlled release bFGF. The devices were by micro-molding thermal assembly 85/15 poly(L-lactide-co-glycolide) sheets. was regulated at 40 ng/day four weeks; bioactivity assessed monitoring 3T3 fibroblasts. proposed can be further miniaturized used individual releasing schedules.
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