Postsurgical Use of Imiquimod 5% Cream in the Prevention of Earlobe Keloid Recurrences: Results of an Open-Label, Pilot Study

摘要: Background. Traditional surgical modalities for the management of earlobe keloids are often associated with high recurrence rates. A recent report suggests that imiquimod 5% cream can be effective in prevention keloid recurrences after excision. Method. To establish safety and efficacy excised keloids. Methods. Patients who attended a dermatologic surgery clinic treatment were recruited into study. Earlobe underwent parallel shave excision. Imiquimod was applied daily 8 weeks followed by an observation period 16 weeks. In patients presented bilateral keloids, paired comparisons versus intralesional steroid injections performed. Results. Eight earlobes treated removal. Twenty-four surgery, six (75%) remained free. Four comparisons. At end period, two (50%) free imiquimod-treated areas while experiencing steroid–treated areas. Local irritation secondary to application required rest periods three cases. all cases, able resume therapy completed study without further complications. Conclusion. Although small uncontrolled, results this open-label, pilot suggest may prove reasonably adjuvant therapeutic alternative keloids. DR. Martin-Garcia HAS BEEN CONSULTANT AND SPEAKER FOR 3M PHARMACEUTICALS.