Updates on old and weary haematopoiesis

摘要: Blood formation, or haematopoiesis, originates from haematopoietic stem cells (HSCs), whose functions and maintenance are regulated in both cell- cell non-autonomous ways. The surroundings of HSCs the bone marrow create a specific niche microenvironment where nest that allows them to retain their unique characteristics respond rapidly external stimuli. Ageing is accompanied by reduced regenerative capacity organism affecting all systems, due progressive decline functions. This includes blood HSCs, which contributes age-related haematological disorders, anaemia, immunosenescence, among others. Furthermore, chronological ageing characterised myeloid platelet HSC skewing, inflammageing, expanded clonal may be result accumulation preleukaemic lesions HSCs. Intriguingly, malignancies such as acute leukaemia have high incidence elderly patients, yet not individuals with haematopoiesis develop leukaemias. Here, we discuss recent work on these aspects, potential underlying molecular mechanisms, first cues linking changes poor maintenance. Future needed for better understanding during ageing. field open new avenues rejuvenation therapeutic strategies elderly.