Nucleic Acid Flow Cytometry in Large Cell Lymphoma

摘要: Between 1978 and 1985, 140 patients with large cell lymphoma (27 follicular, 92 diffuse, 5 immunoblastic, 16 transformed) had DNA-RNA cytometry performed on involved tissue. features were correlated treatment outcome compared to other established prognostic factors in 63 newly diagnosed who received uniformly intensive therapy. Significantly better was noted for previously untreated intermediate RNA content (RNA index, 1.0–1.8), diploid DNA content, (during the initial 12-month follow-up) low proliferative activity. Of followed beyond 12–24 months, those high activity appeared have most durable remissions, although this not statistically significant. These findings suggested a preferential impact of chemotherapy possibly activity, since previous studies our own experience relapsing indicated progressively worse outlook higher index values. In patients, multivariate analysis identified as important factor, by serum lactate dehydrogenase. Thus, lymphoma, appears be valuable prognistic parameter identifying subset likelihood cure chemotherapy.