Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models
作者： Roman Chrast , Gesine Saher , Klaus-Armin Nave , Mark H. G. Verheijen
DOI: 10.1194/JLR.R009761
关键词:
摘要: The integrity of central and peripheral nervous system myelin is affected in numerous lipid metabolism disorders. This vulnerability was so far mostly attributed to the extraordinarily high level synthesis that required for formation myelin, relative autonomy myelinating glial cells because blood barriers shielding from circulating lipids. Recent insights analysis inherited disorders, especially those with prevailing depletion mouse models glia-specific disruption metabolism, shed new light on this issue. particular composition transport lipid-associated proteins, necessity timely assembly sheath all contribute observed perturbed metabolism. Furthermore, uptake external lipids may also play a role membranes. In addition an improved understanding basic biology, these data provide foundation future therapeutic interventions aiming at preserving cell metabolic
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