Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves

摘要: Although Schwann cell myelin breakdown is the universal outcome of a remarkably wide range conditions that cause disease or injury to peripheral nerves, cellular and molecular mechanisms make cell–mediated digestion possible have not been established. We report cells degrade after by novel form selective autophagy, myelinophagy. Autophagy was up-regulated myelinating nerve injury, debris present in autophagosomes, pharmacological genetic inhibition autophagy impaired clearance. Myelinophagy positively regulated JNK/c-Jun pathway, central regulator reprogramming induced injury. also evidence myelinophagy defective injured nervous system. These results reveal an important role for inductive during Wallerian degeneration, point potential mechanistic targets accelerating clearance improving demyelinating disease.