Peroxynitrite activates kinases of the src family and upregulates tyrosine phosphorylation signaling 1,2 1This article is part of a series of reviews on “Reactive Nitrogen Species, Tyrosine Nitration and Cell Signaling.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Harry Ischiropoulos

摘要: The hypothesis that peroxynitrite may act as a signaling molecule able to upregulate protein tyrosine phosphorylation is discussed. This article focuses on the mechanisms for activating kinases of src family, an important class nonreceptor implicated in regulation cell communication, proliferation, migration, differentiation, and survival. Recent vitro findings show erythrocytes, synaptosomes, cerebellar primary culture cells inhibit phosphatases activate different members kinase family through involving cysteine-dependent -independent processes. ability nitrotyrosine-containing peptides with SH2 binding affinity also