Red blood cells as a model to differentiate between direct and indirect oxidation pathways of peroxynitrite.
作者： Maurizio Minetti , Donatella Pietraforte , Elisabetta Straface , Alessio Metere , Paola Matarrese
DOI: 10.1016/S0076-6879(07)00816-6
关键词: Metabolism 、 Peroxynitrite 、 Biochemistry 、 Hemoglobin 、 Chemistry 、 Intracellular 、 Peroxynitrous acid 、 Signal transduction 、 Reactive nitrogen species 、 Apoptosis
摘要: Red blood cells are the major physiological scavengers of reactive nitrogen species and have been proposed as real-time biomarkers some vascular-related diseases. This chapter proposes that erythrocyte is a suitable cell model for studying modifications induced by peroxynitrite. Peroxynitrite decays both extra- intracellularly function density CO(2) concentration, inducing appearance distinct cellular biomarkers, well modulation signaling metabolism. Intracellular oxidations due mostly to direct reactions peroxynitrite with hemoglobin but also lead apoptotic biomarkers. Surface/membrane principally indirect radical generated CO(2)-catalyzed homolysis.
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