Evidence for Transcript Networks Composed of Chimeric RNAs in Human Cells

摘要: The classic organization of a gene structure has followed the Jacob and Monod bacterial model proposed more than 50 years ago. Since then, empirical determinations complexity transcriptomes found in yeast to human blurred definition physical boundaries genes. Using multiple analysis approaches we have characterized individual mapping on chromosomes 21 22. Analyses locations 5' 3' transcriptional termini 492 protein coding genes revealed that for 85% these extend beyond current annotated termini, most often connecting with exons transcripts from other well biological evolutionary importance chimeric is underscored by (1) non-random interconnections involved, (2) greater phylogenetic depth involved many interactions, (3) coordination expression connected (4) close vivo three dimensional proximity genomic regions being transcribed contributing parts RNAs. nature connection suggest should not be studied isolation, but together, as an RNA network.