Influence of Infusion Time on the Acute Toxicity of Amphotericin B: Results of a Randomized Double-Blind Study

摘要: Despite the development of several new antifungal drugs, intravenous amphotericin B (amB) is still considered drug choice for treatment severe systemic fungal infections in immunocompromised patients. However, therapy often limited by various side effects (Table 1). From patients’ point view, acute toxic reactions (fever, chills, nausea and vomiting) induced are particularly troublesome.