Experience with Amphotericin B for the Treatment of Systemic Mycoses

摘要: Amphotericin B is an antibiotic produced by a species of Streptomyces. It appears to have no important antibacterial properties, but possesses highly significant activity against those yeast-like fungi which produce deep mycotic infection in man. Table 1 contains the vitro sensitivities major producers man as determined various investigators.1-3Our own findings, on Sabouraud's dextrose agar at pH 7, are indicated Table. Studies experimental animals2,3have good correlation between vivo effectiveness and sensitivity amphotericin B. Animal toxicity studies carried out Squibb Institute for Medical Research that had therapeutic index sufficient justify clinical trial human infections. Several reports4-6of its use histoplasmosis cryptococcosis already appeared American literature. Routes Administration Toxicity The insolubility crystalline or