Developmental and Hormonal Regulation of the Expression of Oligodendrocyte-Specific Protein/Claudin 11 in Mouse Testis*

摘要: The proliferation and differentiation of testicular progenitor stem cells into highly specialized germ (spermatozoa) are largely controlled by the hormonally (FSH testosterone) regulated adjacent supporting Sertoli cells. However, factors involved in this control remain unknown. In present study, technique differential display PCR was used to identify target transcripts FSH action cultured murine Among these transcripts, we identified oligodendrocyte-specific protein (OSP), also known as claudin 11, which had recently been shown play a key role formation hematotesticular barrier. Our data show that expression OSP is dependent upon male gonad development systemic local signaling molecules. Indeed, expressed early fetal cells, immediately after peak SRY (sex-determining region, Y gene) expression, but just before anti-Mullerian hormone. Postnatally, ...