Leukocyte deformability is a novel biomarker to reflect sepsis-induced disseminated intravascular coagulation.
作者： Miki Morikawa , Yoshiaki Inoue , Yuka Sumi , Yoko Kuroda , Hiroshi Tanaka
DOI: 10.1002/AMS2.54
关键词:
摘要: Aim: Sepsis-induced disseminated intravascular coagulopathy is associated with a high mortality rate. The function and deformability of polymorphonuclear leukocytes change in patients sepsis. goal this study was to characterize the changes leukocyte sepsis-induced evaluate relationship between severity leukocytes. Methods: Thirty-five at our department were enrolled study. These diagnosed severe sepsis an acute score ≥ 4. Blood samples obtained from these on days 1, 3, 7. Polymorphonuclear measured microchannel flow analyzer, activity, represented as CD11b, by cytometry. In contrast, 14 who fulfilled criteria but without complicated also entered Results: coagulopathy, there significant correlation their Japanese Association for Acute Medicine deformability, CD11b expression. became more stiffened expression higher compared condition. Conclusion: correlated response treatment.
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