Genetic variation in the schizophrenia-risk gene neuregulin1 correlates with personality traits in healthy individuals
作者： Axel Krug , Valentin Markov , Dirk Leube , Klaus Zerres , Thomas Eggermann
DOI: 10.1016/J.EURPSY.2008.03.004
关键词:
摘要: Abstract Background Differences in personality traits have long been acknowledged as potential risk factors developing psychiatric disorders. Lately, several susceptibility genes of different disorders linked to traits. This has not done for schizophrenia yet. Neuregulin1 repeatedly shown be associated with and is involved numerous neurodevelopmental functions such neuronal migration myelination. The impact this gene might also modulate healthy subjects. Methods NRG1 status 523 subjects was determined a single nucleotide polymorphism (SNP8NRG221533) which described tagging marker being part the core at-risk haplotype schizophrenia. Genotype correlated using NEO-FFI questionnaire. Results Subjects allele scored higher on neuroticism ( p Conclusions data indicate that found may influence differences
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