Angiogenic and angiostatic microenvironment in tumors--role of gangliosides.

摘要: Gangliosides are important components of the cell membrane that usually shed in surrounding microenvironment by neoplastic cells. can also modulate angiogenic response microvessels stimulated factors. The experiments reported here make a contribution to assessment nature this modulation, demonstrating a) GM3 gangliosides block proliferation endothelium induced cells from human tumors five different origins; b) occurs when endothelial preincubated with and disappears returned medium poor GM3; c) presence capacity bind fibronectin collagen types I IV was sharply reduced; d) concentrations able growth counteracted addition GTlb ganglioside. data suggest prevalence rich prevents proliferation...