Ganglioside Involvement in Tumor Cell—Substratum Interactions

摘要: The process of human tumor proliferation and metastasis undoubtedly involves surface structures that interface with the local environment, i.e., extracellular matrix host tissue. Therefore, it is imperative to understand molecular cell biological events at are associated metastasis. To this end, a major research effort has been directed toward understanding cell-substratum interactions under assumption metastasize, must be able attach invade basement membrane. A number investigators have developed monoclonal antibodies (MAbs) variety antigens allowed for initial characterization some involved in interactions. Several these MAbs define carbohydrate present on glycoproteins, proteoglycans, or glycolipids, which comprise glycocalyx, portion makes contact its environment. Recent technological advances enabled completely characterize structure rather complex tumor-associated defined by recognizing epitopes.(1–12)