Expression and function of ganglioside 9-O-acetyl GD3 in postmitotic granule cell development.
作者： Marcelo F Santiago , Marcia Berredo-Pinho , Marcos R Costa , Mario Gandra , Leny A Cavalcante
关键词:
摘要: We have shown previously that the Jones monoclonal antibody (Jones mAb) recognizes 9-O-acetyl GD3 expressed during periods of neuronal migration and neurite outgrowth in developing rat nervous system. In present study we investigated expression this ganglioside cerebellum correlated with granule cell migration. Electron microscopic immunocytochemistry revealed around peak cerebellar (7-day-old rat), was localized at contact sites between migrating cells radial glia external granular layer prospective molecular layer. addition, using microexplant slice cultures postnatal cerebellum, tested whether detected by our contribute to regulation cortex. mAb blocks neurons a dose-dependent manner. These findings suggest strongly is involved cerebellum.
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