作者: Djana F. Harp , Indrajit Chowdhury
DOI: 10.1016/J.EJOGRB.2011.02.024
关键词:
摘要: Trichomoniasis is the most common sexually transmitted disease, caused by a motile flagellate non-invasive parasitic protozoan, Trichomonas vaginalis (T. vaginalis). More than 160 million people worldwide are annually infected this protozoan. T. occupies an extracellular niche in complex human genito-urinary environment (vagina, cervix, penis, prostate gland, and urethra) to survive, multiply evade host defenses. (strain G3) has ∼160 megabase genome with 60,000 genes, largest number of genes ever identified protozoans. The highly conserved gene family that encodes massive proteome one coding (expressing ∼4000 genes) capacities trophozoite stage, helps adapt survive diverse environment. Based on recent developments field, we review structure, patho-mechanisms, virulence, advances diagnosis therapeutics.