The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein

作者: Diana M. Steel , Alexander S. Whitehead

DOI: 10.1016/0167-5699(94)90138-4

关键词:

摘要: Following an acute phase stimulus, such as infection or physical injury, many liver-derived plasma proteins are increased in concentration. These provide enhanced protection against invading micro-organisms, limit tissue damage and promote a rapid return to homeostasis. Diana Steel Alexander Whitehead discuss the gene structure, regulation possible clinical significance of most dramatically induced reactants.

参考文章(62)
C A Lowell, D A Potter, R S Stearman, J F Morrow, Structure of the murine serum amyloid A gene family. Gene conversion. Journal of Biological Chemistry. ,vol. 261, pp. 8442- 8452 ,(1986) , 10.1016/S0021-9258(19)83932-7
G. Morrone, R. Cortese, V. Sorrentino, Post-transcriptional control of negative acute phase genes by transforming growth factor beta. The EMBO Journal. ,vol. 8, pp. 3767- 3771 ,(1989) , 10.1002/J.1460-2075.1989.TB08553.X
S P Li, T Y Liu, N D Goldman, cis-acting elements responsible for interleukin-6 inducible C-reactive protein gene expression. Journal of Biological Chemistry. ,vol. 265, pp. 4136- 4142 ,(1990) , 10.1016/S0021-9258(19)39713-3
J Gauldie, C D Richards, H Baumann, T J Brown, M Shoyab, Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro. Journal of Immunology. ,vol. 148, pp. 1731- 1736 ,(1992)
X.X. Li, W.S. Liao, Expression of rat serum amyloid A1 gene involves both C/EBP-like and NF kappa B-like transcription factors Journal of Biological Chemistry. ,vol. 266, pp. 15192- 15201 ,(1991) , 10.1016/S0021-9258(18)98603-5