Methods and compositions for the use of HIV env polypeptides and antibodies thereto

摘要: The Human Immunodeficiency Virus envelope protein or its fragments that are capable of binding to the T4 helper lymphocyte receptor used in therapeutically effective doses for treatment immunoinflammatory disorders diseases. Amino acid residues constitue an essential portion domain HIV env fall within a 64 residue sequence extending about from 411 454 3B isolate. This is useful as vaccine component, cytotoxic T cell targeting when conjugated with target substance. which devoid functional immunization against infection. Antibodies this also provided therapeutic and diagnostic use. An immunotoxin comprising monoclonal antibody virally encoded surface antigen, linked toxin such ricin A chain, disclosed. Also, method killing infected cells cells, administering amount