Recombinant immunoglobulin preparations
作者： Arthur Dale Riggs , Herbert Louis Heyneker , Ronald Burnell Wetzel , William Evans Holmes , Shmuel Cabilly
DOI:
关键词:
摘要: PURPOSE: To obtain a recombinant immunoglobulin having improved cell treatment characteristics and antigen-binding properties by transforming host with an expression vector into which heavy chain or light of modified in predetermined manner is inserted culturing the host. CONSTITUTION: A DNA molecule comprising sequence coding for changed specificity to prescribed identified antigen, alteration, deletion addition at least one amino acid from mammalian prepared. At transformed replicable containing operatively bonded proper promoter, recovered culture give objective constant variable regions, specified antigen. COPYRIGHT: (C)1995,JPO
google.co.uk 参考文章(5)
Alan Rowe Williamson, Stuart Airdrie Clark, Heather May Dick, William Howard Stimson, Method of manufacturing monoclonal antibodies and cells capable of manufacturing such antibodies ,(1982)
Haruo Onda, Tsutomu Kurokawa, Masakazu Kikuchi, Recombinant dna, microorganism transformed therewith and use thereof ,(1983)
Arthur D. Levinson, Daniel G. Yansura, Chung-Cheng Liu, Preparation of polypeptides in vertebrate cell culture ,(1982)
Alejandro Zaffaroni, Kevin W. Moore, Hybrid DNA, binding composition prepared thereby and processes therefor ,(1983)
Michael Alan Boss, Clive Ross Wood, John Henry Kenten, John Spencer Emtage, Processes for the production of lg molecules ,(1984)