More than just synaptic building blocks: scaffolding proteins of the post-synaptic density regulate dendritic patterning

摘要: The dendritic arbor is responsible for receiving and consolidating neuronal input. Outgrowth morphogenesis of the are complex stages development that poorly understood. However, recent findings have identified synaptic scaffolding proteins as novel regulators these important events. Scaffolding enriched in post-synaptic density where they bind bring into close proximity neurotransmitter receptors, signaling molecules, actin cytoskeleton. This property spine maintenance mature neuron. now being described key neurite outgrowth, development, pattern formation immature neurons. These proteins, which include post-synaptic-95, Shank Densin-180, well many their interacting partners, appear to regulate both microtubule cytoskeleton influence dendrite morphology. Through a large array protein-protein interaction domains, able form macromolecular complexes cytoskeletal motor regulatory molecules. Together, new persuasive argument deliver critical elements sites outgrowth branching modulate arbor.