PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands

摘要: Localizing cell surface receptors to specific subcellular positions can be critical for their proper functioning, as most notably demonstrated at neuronal synapses. PDZ proteins apparently play roles in such protein localizations. Receptor tyrosine kinases have not been previously shown interact with vertebrates. We report that Eph and membrane-linked ligands all contain recognition motifs bind clustered by proteins. In addition, we find colocalize Thus, may localizing vertebrate receptor and/or particularly important function guidance or patterning the synapse.