Molecular mechanism of central nervous system repair by the Drosophila NG2 homologue kon-tiki
作者： Maria Losada-Perez , Neale Harrison , Alicia Hidalgo
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摘要: Neuron glia antigen 2 (NG2)–positive are repair cells that proliferate upon central nervous system (CNS) damage, promoting functional recovery. However, is limited because of the failure newly produced glial to differentiate. It a key goal discover how regulate NG2 enable proliferation and differentiation conducive repair. Drosophila has an homologue called kon-tiki ( kon ), unknown CNS function. We show promotes identify underlying mechanism. Crush injury up-regulates expression downstream Notch. Kon in turn induces initiates by activating genes prospero pros ). Two negative feedback loops with Notch Pros allow drive homeostatic regulation required for By modulating levels glia, we could prevent or promote Thus, links between Kon, Notch, essential for, can drive, Analogous mechanisms mammals.
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