Platelet deposition in non-parallel flow: influence of shear stress and changes in surface reactivity.

摘要: This paper deals with flow- and surface-related aspects of primary hemostasis. It investigates the influence both shear stress changes in surface reactivity on platelet adhesion. For this purpose, a mathematical model based Navier-Stokes equations particle conservation is developed. Several vessel geometries physiological relevance are considered, such as stagnation point flow, sudden expansion t-junction. Model parameters have been optimized to fit corresponding experimental data. When adhesion was assumed independent shear, numerically predicted spatial distribution did not match these data at all. However, when shear-dependent, better agreement achieved. Further improvement obtained due were taken into account. done by coupling flux conditions ordinary differential for evolution surface-bound platelets. Existence weak solutions shown generalized parabolic systems having boundary conditions. This, together proofs uniqueness positivity solutions, guarantees well posedness presented model. Limitations complexity hemostatic system discussed, possible applications practice. The findings contribute understand roles flow hemostasis, which paramount interest bioengineering clinical