Emerging trends of HIV epidemiology in Asia.

摘要: The main molecular trait of HIV-1 is the inherent capacity to vary, recombine, and diversify, which gives it a clear edge evade human immune system survive through generation complex forms, termed recombinants. In setting coinfection, biological interactions between diverse subtypes may promote emergence circulating recombinant forms shuffling viral genomes, results in increased intra- inter- host variation altered properties. focus this review on Asia, has highest proportion recombinants worldwide, with top South Southeast amounting 89% its total infection. strains are spreading geographic area CRF01_AE, B C. Given rapid spread active establishment some essential understand how they differ from their parental strains, acquisition certain traits, attributes upon recombination, give these an epidemiologic edge. current epidemic provides strong evidence that being replaced via competition possibly more versatile forms. This appears be ongoing phenomenon resulted shift, expansion dissemination wide variety within region.