Diversity of mosaic structures and common ancestry of human immunodeficiency virus type 1 BF intersubtype recombinant viruses from Argentina revealed by analysis of near full-length genome sequences.

摘要: The findings that BF intersubtype recombinant human immunodeficiency type 1 viruses (HIV-1) with coincident breakpoints in pol are circulating widely Argentina and non-recombinant F subtype have failed to be detected this country were reported recently. To analyse the mosaic structures of these determine their phylogenetic relationship, near full-length proviral genomes eight amplified by PCR sequenced. Intersubtype analysed bootscanning examining signature nucleotides. Phylogenetic relationships determined neighbour-joining trees. Five viruses, each predominantly genomes, exhibited highly similar. Two shared all seven majority. Of consensus breakpoints, nine present two which identical structures, four remaining viruses. analysis partial sequences supported both a common ancestry, at least part for relationship segments from Brazil. A ancestry recombinants was also presence amino acids nucleotides, either unreported or unusual B These results indicate HIV-1 diverse including form (which widespread Argentina) derive ancestor related phylogenetically