The K(+) channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia.

作者: Dinah Nockemann , Morgane Rouault , Dominika Labuz , Philip Hublitz , Kate McKnelly

DOI: 10.1002/EMMM.201201980

关键词:

摘要: … of GIRK2 transcript in DRG of Na v 1.8-GIRK2 mice confirming that the Na v 1.8 promoter drives expression in sensory neurons (Fig 3A). We observed no alterations in GIRK2 mRNA …

参考文章(54)
Jeannette Endres-Becker, Paul A. Heppenstall, Shaaban A. Mousa, Dominika Labuz, Alexander Oksche, Michael Schäfer, Christoph Stein, Christian Zöllner, μ-Opioid Receptor Activation Modulates Transient Receptor Potential Vanilloid 1 (TRPV1) Currents in Sensory Neurons in A Model of Inflammatory Pain Molecular Pharmacology. ,vol. 71, pp. 12- 18 ,(2007) , 10.1124/MOL.106.026740
Christine Karschin, Elke Dißmann, Walter Stühmer, Andreas Karschin, IRK(1–3) and GIRK(1–4) Inwardly Rectifying K+Channel mRNAs Are Differentially Expressed in the Adult Rat Brain The Journal of Neuroscience. ,vol. 16, pp. 3559- 3570 ,(1996) , 10.1523/JNEUROSCI.16-11-03559.1996
Alla Khodorova, Betsy Navarro, Laurence Sophie Jouaville, Jo-Ellen Murphy, Frank L Rice, Joseph E Mazurkiewicz, Denise Long-Woodward, Markus Stoffel, Gary R Strichartz, Rus Yukhananov, Gudarz Davar, Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury Nature Medicine. ,vol. 9, pp. 1055- 1061 ,(2003) , 10.1038/NM885
Christian Lüscher, Paul A. Slesinger, Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease Nature Reviews Neuroscience. ,vol. 11, pp. 301- 315 ,(2010) , 10.1038/NRN2834
D. J. Cavanaugh, H. Lee, L. Lo, S. D. Shields, M. J. Zylka, A. I. Basbaum, D. J. Anderson, Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 9075- 9080 ,(2009) , 10.1073/PNAS.0901507106
Cheryl L Marker, Markus Stoffel, Kevin Wickman, Spinal G-Protein-Gated K+ Channels Formed by GIRK1 and GIRK2 Subunits Modulate Thermal Nociception and Contribute to Morphine Analgesia The Journal of Neuroscience. ,vol. 24, pp. 2806- 2812 ,(2004) , 10.1523/JNEUROSCI.5251-03.2004
Daniel W. Beacham, Trillium Blackmer, Michael O’ Grady, George T. Hanson, Cell-Based Potassium Ion Channel Screening Using the FluxOR™ Assay: Journal of Biomolecular Screening. ,vol. 15, pp. 441- 446 ,(2010) , 10.1177/1087057109359807
Stephanie L. Borgland, Mark Connor, MacDonald J. Christie, Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganglion neurons in mouse The Journal of Physiology. ,vol. 536, pp. 35- 47 ,(2001) , 10.1111/J.1469-7793.2001.T01-1-00035.X
Gary Franklin, Leonard Paulozzi, Tanja Popovic, Gil Kerlikowske, Neelam Ghiya, Grant Baldwin, Christopher M. Jones, CDC grand rounds Morbidity and Mortality Weekly Report. ,vol. 61, pp. 10- 13 ,(2012)
Laura Hernández, Asunción Romero, Pilar Almela, Paula García-Nogales, M. Luisa Laorden, Margarita M. Puig, Tolerance to the antinociceptive effects of peripherally administered opioids. Expression of beta-arrestins. Brain Research. ,vol. 1248, pp. 31- 39 ,(2009) , 10.1016/J.BRAINRES.2008.10.065