Usefulness of technetium-99m tetrofosmin liver imaging to detect hepatocellular carcinoma and related to expression of P-glycoprotein or multidrug resistance associated protein–a preliminary report

摘要: Technetium-99m Tetrofsomin (Tc-TF) has been shown to be useful in identifying several types of tumors, such as breast, lung, and thyroid cancers. There was no report the literature for Tc-TF uptake hepatocellular carcinoma (HCC). The aim this study evaluate usefulness liver imaging detect HCC investigate relationship between findings P-glycoprotein (Pgp) multidrug resistance associated protein (MRP) expression. Before any therapy, 22 patients with were enrolled study. images performed l0 minutes after intravenous injection 20mCi Tc-TF. All had biopsy or surgery within l week imaging. Immunohistochemical resected specimens using anti-human Pgp MRP antibodies. Twenty (90.9%) showed negative results without significant HCC, whereas only remaining 2 (9.1%) positive HCC. Positive expression observed 13 20 results, 6 7 both However, but all results. correlation better than may induce resulting findings. Therefore, is potential a non-invasive method predict further studies larger series longer follow-up time are necessary confirm our