A T cell receptor transgenic model of severe, spontaneous organ-specific autoimmunity.

摘要: The development of mouse models human organ-specific autoimmune diseases has been hampered by the need to immunize mice with autoantigens in potent adjuvants. Even autoantigen-specific T cell receptor transgenic autoimmunity have proven be complex as frequently fail develop disease spontaneously. We isolated a CD4+ clone (TxA23)that recognizes gastric parietal antigen, H/K ATPase α-chain630–641, from gastritis that developed after thymectomy on day 3 life. α and β genes this were used generate A23 mice. All animals spontaneously severe gastritis, evidence was detected early day 10 Gastritis could transferred immunocompromised limited number thymocytes (103), but many 107 induced only mild wild-type animals. Due complete penetrance spontaneous disease, identity auto-antigen, susceptibility immunoregulation, close relation man, represent unique cell-mediated model for understanding multiple factors regulating autoimmunity.