The underlying cellular mechanism of fibrosis.

摘要: Fibrosis is a common sequela of various exogenous insults to variety parenchymal tissues. The underlying mechanisms the induction and progression fibrosis both at molecular cellular level have not been clarified so far. In present study processes that ultimately may lead interstitial are described using model radiation-induced terminal differentiation in fibroblast/fibrocyte cell system. data reported herein will provide evidence exogenously induced changes proliferation pattern system based on either autocrine and/or paracrine mediators represent mechanism fibrosis. Using co-culture systems cells (fibroblasts type II pneumocytes), intercellular communication via cytokines, which studied. TGF beta 1 could be as one key modulator these processes.