Acute Hepatitis C in a Contemporary US Cohort: Modes of Acquisition and Factors Influencing Viral Clearance

摘要: Background. Acute hepatitis C virus (HCV) infection is often asymptomatic; thus, its epidemiology and natural history are difficult to define. Methods. HCV was identified on the basis of seroconversion within 1 year (n = 45 new anti-HCV seropositivity with clinical acute 21), or strain sequencing after an iatrogenic exposure 1). Risk factors were assessed a baseline questionnaire, participants followed up prospectively serial measurement viral loads. Results. Of 67 persons infection, most asymptomatic (64%) injection drug users (66%). Thirteen had unknown mode transmission; these, 11 reported high-risk sexual behavior. Ten acquired 3 months exposure; confirmed 4 no other risk identified. The spontaneous clearance rate 6 18% (95% confidence interval, 11%-31%). varied significantly by sex (34% vs. 3% for women men; P <. 001). Conclusions. High-risk exposures may be important contemporary infection. (18%) in this study similar that past studies transfusion-associated Women more likely clear than men.