Effects of sulfur amino acids on tyrosyl or serine/threonine phosphorylation and translocation of cytosolic compounds to cell membrane in stimulus-treated human neutrophils.
作者： Noriko Kitaoka , Hidehiro Abe , Hiroyuki Kodama , Gang Liu , Koichi Yamashita
DOI: 10.18926/AMO/31829
关键词:
摘要: We investigated the effects of various sulfur amino acids on phosphorylation proteins and translocation cytosolic compounds to cell membrane in stimulus-treated human neutrophils using specific monoclonal antibodies. D,L-homocysteine D,L-homocysteine-thiolactone enhanced fMLP-induced tyrosyl p47phox, p67phox, rac a concentration-dependent manner. L-cystathionine, NAc-L-cysteine carboxymethylcysteine suppressed phophorylation membrane. L-cysteine PMA-induced serine/threonine L-cysteine, AA-induced membrane, but L-cystathionine had opposite effects. These results indicated that or were parallel with those stimulus-induced superoxide generation reported previous paper. weakly inhibited lipid peroxidation, other tested no effect.
okayama-u.ac.jp
sci-hub.st 参考文章(30)
B M Babior, J el Benna, J el Benna, R M Smith, S J Chanock, The respiratory burst oxidase. Journal of Biological Chemistry. ,vol. 269, pp. 24519- 24522 ,(1994) , 10.1016/S0021-9258(17)31418-7
Bernard M. Babior, NADPH Oxidase: An Update Blood. ,vol. 93, pp. 1464- 1476 ,(1999) , 10.1182/BLOOD.V93.5.1464
W M Nauseef, B D Volpp, S McCormick, K G Leidal, R A Clark, Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components. Journal of Biological Chemistry. ,vol. 266, pp. 5911- 5917 ,(1991) , 10.1016/S0021-9258(19)67684-2
Wenfei He, Gang Liu, Xin Chen, Jincai Lu, Hidehiro Abe, Kexin Huang, Masanobu Manabe, Hiroyuki Kodama, Inhibitory effects of ginsenosides from the root of Panax ginseng on stimulus-induced superoxide generation, tyrosyl or serine/threonine phosphorylation, and translocation of cytosolic compounds to plasma membrane in human neutrophils. Journal of Agricultural and Food Chemistry. ,vol. 56, pp. 1921- 1927 ,(2008) , 10.1021/JF073364K
Ryutaro Takahashi, Keisuke Edashige, Eisuke F. Sato, Masayasu Inoue, Tsuyoshi Matsuno, Kozo Utsumi, Luminol chemiluminescence and active oxygen generation by activated neutrophils Archives of Biochemistry and Biophysics. ,vol. 285, pp. 325- 330 ,(1991) , 10.1016/0003-9861(91)90367-R
Kouichirou Wada, Yoshinori Kamisaki, Masayuki Kitano, Kentaro Nakamoto, Tadao Itoh, Protective effect of cystathionine on acute gastric mucosal injury induced by ischemia-reperfusion in rats European Journal of Pharmacology. ,vol. 294, pp. 377- 382 ,(1995) , 10.1016/0014-2999(95)00558-7
Lydia M. Henderson, J.Brian Chappell, NADPH oxidase of neutrophils. Biochimica et Biophysica Acta. ,vol. 1273, pp. 87- 107 ,(1996) , 10.1016/0005-2728(95)00140-9
Kouichirou Wada, Yoshinori Kamisaki, Kentaro Nakamoto, Tadao Itoh, Effect of cystathionine as a scavenger of superoxide generated from human leukocytes or derived from xanthine oxidase in vitro. European Journal of Pharmacology. ,vol. 296, pp. 335- 340 ,(1996) , 10.1016/0014-2999(95)00717-2
Cha-Kwon Chung, Myung-Eun Jung, Ethanol Fraction of Aralia elata Seemann Enhances Antioxidant Activity and Lowers Serum Lipids in Rats When Administered with Benzo(α)pyrene Biological & Pharmaceutical Bulletin. ,vol. 26, pp. 1502- 1504 ,(2003) , 10.1248/BPB.26.1502
Morimitsu Nishikimi, N. Appaji Rao, Kunio Yagi, The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen Biochemical and Biophysical Research Communications. ,vol. 46, pp. 849- 854 ,(1972) , 10.1016/S0006-291X(72)80218-3