Protective effect of cystathionine on acute gastric mucosal injury induced by ischemia-reperfusion in rats
作者： Kouichirou Wada , Yoshinori Kamisaki , Masayuki Kitano , Kentaro Nakamoto , Tadao Itoh
DOI: 10.1016/0014-2999(95)00558-7
关键词:
摘要: We studied the protective effect of cystathionine on acute gastric mucosal injury induced by ischemia-reperfusion in rats. Under pentobarbital anesthesia, celiac artery was clamped for 30 min and reperfused. Sixty minutes after reperfusion, total area erosions thiobarbituric acid-reactive substances stomach, as an index lipid peroxidation, were measured compared between control cystathionine-treated groups. Intraperitoneal administration (1-20 mg/kg) 10 before ischemia significantly reduced both level substances. When (10 administered orally, significant reductions also observed. There a good correlation Cystathionine did not affect blood flow during ischemia-reperfusion. These results indicate that may be due to scavenging action against superoxide radicals vivo.
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sci-hub.se 参考文章(20)
S. Morgan Smith, Matthew B. Grisham, Elizabeth A. Manci, D. Neil Granger, Peter R. Kvietys, Janice M. Russell, Gastric Mucosal Injury in the Rat Gastroenterology. ,vol. 92, pp. 950- 956 ,(1987) , 10.1016/0016-5085(87)90969-3
Makoto Itoh, Paul H. Guth, Role of Oxygen-Derived Free Radicals in Hemorrhagic Shock-Induced Gastric Lesions in the Rat Gastroenterology. ,vol. 88, pp. 1162- 1167 ,(1985) , 10.1016/S0016-5085(85)80075-5
Michael A. Perry, Surjit Wadhwa, Dale A. Parks, Wes Pickard, D.Neil Granger, Role of oxygen radicals in ischemia-induced lesions in the cat stomach Gastroenterology. ,vol. 90, pp. 362- 367 ,(1986) , 10.1016/0016-5085(86)90933-9
John A. Buege, Steven D. Aust, Microsomal lipid peroxidation. Methods in Enzymology. ,vol. 52, pp. 302- 310 ,(1978) , 10.1016/S0076-6879(78)52032-6
Y Kamisaki, Y Kitamura, T Itoh, Hepatoprotective effects of cystathionine against acetaminophen-induced necrosis. Journal of Pharmacology and Experimental Therapeutics. ,vol. 250, pp. 667- 671 ,(1989)
Aws S. Salim, Oxygen-Derived Free Radicals and the Prevention of Duodenal Ulcer Relapse: A New Approach The American Journal of the Medical Sciences. ,vol. 300, pp. 1- 6 ,(1990) , 10.1097/00000441-199007000-00001
Masahiko Hirota, Masayasu Inoue, Yukio Ando, Yoshimasa Morino, Inhibition of stress-induced gastric mucosal injury by a long acting superoxide dismutase that circulates bound to albumin Archives of Biochemistry and Biophysics. ,vol. 280, pp. 269- 273 ,(1990) , 10.1016/0003-9861(90)90329-W
T D Engerson, T G McKelvey, D B Rhyne, E B Boggio, S J Snyder, H P Jones, Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues. Journal of Clinical Investigation. ,vol. 79, pp. 1564- 1570 ,(1987) , 10.1172/JCI112990
Istvan Szelenyi, Kay Brune, Possible role of oxygen free radicals in ethanol-induced gastric mucosal damage in rats Digestive Diseases and Sciences. ,vol. 33, pp. 865- 871 ,(1988) , 10.1007/BF01550977
Takuji Mizui, Hatsuo Sato, Fumiaki Hirose, Masami Doteuchi, Effect of antiperoxidative drugs on gastric damage induced by ethanol in rats Life Sciences. ,vol. 41, pp. 755- 763 ,(1987) , 10.1016/0024-3205(87)90456-5