Cytoprotective activity of mulberry leaf extract against oxidative stress-induced cellular injury in rats.

摘要: Morus alba Linn. (MA), mulberry leaves have been used as a beverage for prevention of various diseases including hyperlipidemia and hyperglycemia. Recently, the antioxidant activities MA leaf extract reported. The objective this study was to investigate effect on free radical-induced cellular injury. In in vitro models, scavenged stable radical (1, 1-diphenyl-2-picrylhydrazyl; DPPH) concentration-dependent manner with an IC(50) 20.10 ± 0.78 μ g/ml. protected erythrocytes from (2, 2'-azobis (2-amidinopropane) dihydrochloride; AAPH)-induced hemolysis 74.22 9.87 μg/ml. Additionally, significantly prevented gastric mucosal injury induced by ischemia-reperfusion (I/R) rats when given orally at doses 0.25 0.50 g/kg/day 3 consecutive days (p < 0.05; n=7). However, not found higher (1 2 g/kg/day) were tested. conclusion, these results indicate that possesses cytoprotective activity against cell Therefore, appropriate dose range, may potentially be food supplement patients certain which oxidative stress-induced is pathologically involved.