Carpal tunnel pressure alters median nerve function in a dose-dependent manner: a rabbit model for carpal tunnel syndrome.

摘要: Abstract Background: An in vivo animal model for carpal tunnel syndrome (CTS) is presented which allows graded application of pressure to the median nerve within canal. We hypothesized that such would cause electrophysiologic changes a dose-related manner, with NCS/EMG consistent CTS humans. Methods: In 40 New Zealand white rabbits, ranging from 2 2.5 kg, angioplasty catheters were placed forepaws and pressures 50 80 mm Hg applied one side while contralateral served as control remained uninflated. Pressure was until 15% increase distal motor latency obtained consecutive weeks by conduction studies. Results: All experimental limbs exhibited latency. None showed significant animals delay achieved approximately 4–5 50–70 groups 1 week group. Conclusion: This new demonstrates direct effect relationship between dysfunction. anticipate this clinically relevant outcomes will facilitate identification injury mechanisms, serve basis future development novel interventions treatments.