The disposition of free and niosomally encapsulated Rac-flurbiprofen in dairy bovines.
作者： E. O. CONFALONIERI , A. L. SORACI , M. BECALUBA , L. DENZOIN , E. RODRIGUEZ
DOI: 10.1111/J.1365-2885.2009.01095.X
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摘要: Confalonieri, E. O., Soraci, A. L., Becaluba, M., Denzoin, Rodriguez, E., Riccio, B., Tapia, O. The disposition of free and niosomally encapsulated Rac-flurbiprofen in dairy bovines. J. vet. Pharmacol. Therap. 33, 9–14. Pharmacokinetic parameters were established for flurbiprofen (FBP) after intravenous (i.v.) administration (0.5 mg/kg) niosomal nonniosomal formulations cattle. Niosomes FBP showed a drug loading 92.0 ± 0.7% the niosomes to cattle did not produce any immunological reaction associated components. Niosomal was slowly eliminated from plasma mean residual time (MRT) AUC0t t 1/2 values significantly higher than those non formulations. results presented this study indicate that long circulation offers potential application improving pharmacokinetic short half-life drugs clinical use. offer new promising perspectives delivery modules bovine therapeutics.
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blackwell-synergy.com参考文章(45)
N. K Jain, Alok Namdeo, Niosomes As Drug Carriers Indian Journal of Pharmaceutical Sciences. ,vol. 58, pp. 41- 46 ,(1996)
R J Kulmacz, W E Lands, Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents. Journal of Biological Chemistry. ,vol. 260, pp. 12572- 12578 ,(1985) , 10.1016/S0021-9258(17)38909-3
L Igarza, A Soraci, N Auza, H Zeballos, Pharmacokinetic parameters of (R)-(-) and (S)-(+)-flurbiprofen in dairy bovines. Veterinary Research Communications. ,vol. 30, pp. 513- 522 ,(2006) , 10.1007/S11259-006-3241-4
Parveen Goyal, Kumud Goyal, Sengodan Gurusamy Vijaya Kumar, AJIT Singh, Om Prakash Katare, Dina Nath Mishra, None, Liposomal drug delivery systems - Clinical applications Acta Pharmaceutica. ,vol. 55, pp. 1- 25 ,(2005)
Ijeoma F. Uchegbu, John A. Double, John A. Turton, Alexander T. Florence, Distribution, metabolism and tumoricidal activity of doxorubicin administered in sorbitan monostearate (Span 60) niosomes in the mouse. Pharmaceutical Research. ,vol. 12, pp. 1019- 1024 ,(1995) , 10.1023/A:1016210515134
C D Funk, D L Dewitt, T Hla, O Laneuville, D K Breuer, W L Smith, Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. Journal of Pharmacology and Experimental Therapeutics. ,vol. 271, pp. 927- 934 ,(1994)
K. C. CARTER, T. F. DOLAN, J. ALEXANDER, A. J. BAILLIE, C. MCCOLGAN, Visceral Leishmaniasis: Drug Carrier System Characteristics and the Ability to Clear Parasites from the Liver, Spleen and Bone Marrow in Leishmania donovani Infected BALB/c Mice Journal of Pharmacy and Pharmacology. ,vol. 41, pp. 87- 91 ,(2011) , 10.1111/J.2042-7158.1989.TB06399.X
Ijeoma F. Uchegbu, Alexander T. Florence, Non-ionic surfactant vesicles (niosomes): Physical and pharmaceutical chemistry Advances in Colloid and Interface Science. ,vol. 58, pp. 1- 55 ,(1995) , 10.1016/0001-8686(95)00242-I
Manuela Voinea, Maya Simionescu, Designing of ‘intelligent’ liposomes for efficient delivery of drugs Journal of Cellular and Molecular Medicine. ,vol. 6, pp. 465- 474 ,(2002) , 10.1111/J.1582-4934.2002.TB00450.X
PETER LEES, JIM RIVIERE, JONATHAN ELLIOTT, JVPT in 2005 and beyond Journal of Veterinary Pharmacology and Therapeutics. ,vol. 28, pp. 1- 1 ,(2005) , 10.1111/J.1365-2885.2004.00643.X