Accumulation of ALDH1-positive cells after neoadjuvant chemotherapy predicts treatment resistance and prognosticates poor outcome in ovarian cancer

摘要: Although ovarian cancer is a highly chemosensitive disease, it only infrequently cured. One of the major reasons lies in presence drug-resistant stem-like cells, sufficient to fuel recurrence. We phenotyped cells by flow cytometry and immunohistochemistry 55 matched samples before after taxane/platinum-based neoadjuvant chemotherapy. All used markers stemness (ALDH1, CD24, CD117, CD133) isolated low frequencies malignant cells. ALDH1 was most valuable marker for tracking vivo. The enrichment expression treatment associated with poor response chemotherapy, platinum resistance independently prognosticated unfavorable outcome. Our results suggest that increased identifies patients aggressive tumor phenotypes.